BACKGROUND The MYST proteins, characterized by a highly conserved acetyltransferase domain, are involved in a wide range of physiological processes in mammals, ranging from the development of the nervous system to that of the hematopoietic

BACKGROUND MOF, known as hMOF/MYST1/KAT8 in humans, is an acetyltransferase conserved among higher eukaryotes, which specifically acetylates histone H4 at lysine 16 (H4K16ac). A single histone H4K16ac modification modulates both higher-order chromatin structure and functional